MCSF Receptor Antibody, ALEXA FLUOR 488

Gene ID Number 1436

Modification Site None

Swiss Prot P07333

French translation anticorps

Modification Unmodified

Clonality Polyclonal

Excitation emission 499nm/519nm

Concentration 1ug per 1ul

Immunogen range 200-245/972

Conjugation Alexa Fluor

Target Antigen MCSF Receptor

Subcellular location Extracellular

Tested applications FCM, IF(IHC-P)

Crossreactivity Human, Mouse, Rat

Conjugated with ALEXA FLUOR® 488

Clone Polyclonal antibody

Purification Purified by Protein A.

Category Conjugated Primary Antibodies

Host Organism Rabbit (Oryctolagus cuniculus)

Recommended dilutions FCM(1:20-100), IF(IHC-P)(1:50-200)

Also known as Anti-MCSF Receptor PAb ALEXA FLUOR 488

Specificity This is a highly specific antibody against MCSF Receptor.

Long name MCSF Receptor Polyclonal Antibody, ALEXA FLUOR 488 Conjugated

Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MCSF receptor

Synonyms FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; Proto-oncogene c-Fms; CSF1R

Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties For facs or microscopy Alexa 1 conjugate.Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-MCSF Receptor has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Description The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

Background of the antigen The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]