M-CSF Receptor(Tyr546) Antibody, Biotin Conjugated

Excitation Emission N/A

Gene ID number 1436

Conjugation Biotin

Modification site Tyr546

French translation anticorps

Tested applications WB, IHC-P

Clonality Polyclonal

Concentration 1ug per 1ul

Additional conjugation Biotinylated

Modification Phosphorylation

Crossreactivity Human, Mouse, Rat

Clone Polyclonal antibody

Target Antigen M-CSF Receptor Tyr546

Category Conjugated Primary Antibodies

Host Organism Rabbit (Oryctolagus cuniculus)

Recommended dilutions WB(1:100-1000), IHC-P(1:100-500)

Purification method This antibody was purified via Protein A.

Long name M-CSF Receptor(Tyr546) Antibody, Biotin Conjugated

Specificity This is a highly specific antibody against M-CSF Receptor Tyr546.

Crossreactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source KLH conjugated synthetic phosphopeptide derived from human CSF1R around the phosphorylation site of tyrosine 546

Storage conditions Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.

Synonyms C FMS; CD 115; CD115; CD115 antigen; CFMS; Colony stimulating factor 1 receptor; Colony stimulating factor I receptor; CSF 1 R; CSF 1R; CSF1 R; CSF1R; CSFR; FIM 2; FIM2; CSF1R_HUMAN

Properties If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.

Description The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

Antigen background This protein tyrosine kinase transmembrane receptor is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a member of the CSF1/PDGF receptor family of tyrosine protein kinases and contains 5 immunoglobulin like C2 type domains. CD115 is expressed by cells of the monocytic lineage and by progenitor cells. Mutations in this gene have been associated with a predisposition to myeloid malignancy.