Gene ID number 1436
Swiss Prot P07333
French translation anticorps
Concentration 1ug per 1ul
Immunogen range 200-245/972
Target Antigen MCSF Receptor
Subcellular location Extracellular
Cross reactivity Human, Mouse, Rat
Also known as MCSF Receptor PAb
Category Primary Antibodies
Modification site(s) Unmodified antibody
Clonality Polyclonal antibody
Clone number Polyclonal antibody
Tested Applications WB, FCM, IHC-P, IF(IHC-P)
Long name MCSF Receptor Primary Polyclonal Antibody
Purification method This antibody was purified via Protein A.
Specificity This is a highly specific antibody against MCSF Receptor.
Recommended dilutions WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Cross reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MCSF receptor
Storage conditions Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
Synonym names FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; Proto-oncogene c-Fms; CSF1R
Properties If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Description The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
Background of the target antigen The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]