Anti-MCSF Receptor (Polyclonal), ALEXA Fluor 594

Gene ID 1436

Modification site None

Swiss Prot P07333

Excitation emission 590nm/617nm

Concentration 1ug per 1ul

Subcellular locations Extracellular

Target Protein/Peptide MCSF Receptor

Applications FCM, IF(IHC-P)

Conjugated Alexa conjugate 1

Conjugated with ALEXA FLUOR® 594

Clonality Polyclonal Antibody

Clone Polyclonal Antibodies

Purification method Purified by Protein A.

Group Polyclonals and antibodies

Type Conjugated Primary Antibody

Other name Anti-MCSF Receptor Polyclonal

Conjugation Alexa Fluor,ALEXA FLUOR® 594

Host organism Rabbit (Oryctolagus cuniculus)

Also known as MCSF Receptor Polyclonal Antibody

Applications with corresponding dilutions FCM(1:20-100), IF(IHC-P)(1:50-200)

Properties For facs or microscopy Alexa 1 conjugate.

Modification No modification has been applied to this antibody

Specificity This antibody reacts specifically with MCSF Receptor

Antigen Source KLH conjugated synthetic peptide derived from human MCSF receptor

Cross reactive species Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)

Storage Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.

Synonyms FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; Proto-oncogene c-Fms; CSF1R

About Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

Cross Reactive Species details No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.

Advisory Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.

Background information The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.