Gene ID Number 1436
Modification Site Tyr546
Tested applications IF(IHC-P)
French translation anticorps
Concentration 1ug per 1ul
Excitation emission 650nm/665nm
Conjugated with ALEXA FLUOR® 647
Crossreactivity Human, Mouse, Rat
Recommended dilutions IF(IHC-P)(1:50-200)
Clone Polyclonal antibody
Target Antigen M-CSF Receptor Tyr546
Purification Purified by Protein A.
Conjugation Alexa Fluor,ALEXA FLUOR 647
Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Also known as Anti-M-CSF Receptor Tyr546 PAb ALEXA FLUOR 647
Long name M-CSF Receptor(Tyr546) Antibody, ALEXA FLUOR 647 Conjugated
Specificity This is a highly specific antibody against M-CSF Receptor Tyr546.
Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Source KLH conjugated synthetic phosphopeptide derived from human CSF1R around the phosphorylation site of tyrosine 546
Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Synonyms C FMS; CD 115; CD115; CD115 antigen; CFMS; Colony stimulating factor 1 receptor; Colony stimulating factor I receptor; CSF 1 R; CSF 1R; CSF1 R; CSF1R; CSFR; FIM 2; FIM2; CSF1R_HUMAN
Description The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
Background of the antigen This protein tyrosine kinase transmembrane receptor is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a member of the CSF1/PDGF receptor family of tyrosine protein kinases and contains 5 immunoglobulin like C2 type domains. CD115 is expressed by cells of the monocytic lineage and by progenitor cells. Mutations in this gene have been associated with a predisposition to myeloid malignancy.
Properties For facs or microscopy Alexa 1 conjugate.Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-M-CSF Receptor Tyr546 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.