Gene ID Number 1436
Modification Site None
Swiss Prot P07333
French translation anticorps
Excitation emission 343nm/442nm
Concentration 1ug per 1ul
Immunogen range 200-245/972
Target Antigen MCSF Receptor
Subcellular location Extracellular
Tested applications FCM, IF(IHC-P)
Conjugated with ALEXA FLUOR® 350
Crossreactivity Human, Mouse, Rat
Clone Polyclonal antibody
Purification Purified by Protein A.
Conjugation Alexa Fluor,ALEXA FLUOR 350
Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Recommended dilutions FCM(1:20-100), IF(IHC-P)(1:50-200)
Also known as Anti-MCSF Receptor PAb ALEXA FLUOR 350
Specificity This is a highly specific antibody against MCSF Receptor.
Long name MCSF Receptor Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MCSF receptor
Synonyms FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; Proto-oncogene c-Fms; CSF1R
Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Properties For facs or microscopy Alexa 1 conjugate.Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Description The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
Background of the antigen The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]