Gene ID number 1436
Modification site None
Swiss Prot P07333
French translation anticorps
Concentration 1ug per 1ul
Subcellular location Extracellular
Target Antigen MCSF Receptor
Tested applications FCM, IF(IHC-P)
Crossreactivity Human, Mouse, Rat
Clone Polyclonal antibody
Additional conjugation cy3 conjugation kit
Excitation Emission 512,550nm/570,615nm
Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Recommended dilutions FCM(1:20-100), IF(IHC-P)(1:50-200)
Purification method This antibody was purified via Protein A.
Long name MCSF Receptor Polyclonal Antibody, Cy3 Conjugated
Specificity This is a highly specific antibody against MCSF Receptor.
Source KLH conjugated synthetic peptide derived from human MCSF receptor
Crossreactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Synonyms FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; Proto-oncogene c-Fms; CSF1R
Storage conditions Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
Properties If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the Anti-MCSF Receptor can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.
Description The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
Antigen background The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]