Gene ID number 1436
Modification site(s) Tyr546
French translation anticorps
Concentration 1ug per 1ul
Cross reactivity Human, Mouse, Rat
Category Primary Antibodies
Clonality Polyclonal antibody
Clone number Polyclonal antibody
Tested Applications WB, IHC-P, IF(IHC-P)
Target Antigen M-CSF Receptor Tyr546
Long name M-CSF Receptor(Tyr546) Antibody
Also known as M-CSF Receptor(Tyr546) Antibody
Purification method This antibody was purified via Protein A.
Recommended dilutions WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Specificity This is a highly specific antibody against M-CSF Receptor Tyr546.
Cross reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Source KLH conjugated synthetic phosphopeptide derived from human CSF1R around the phosphorylation site of tyrosine 546
Storage conditions Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
Properties If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Synonym names C FMS; CD 115; CD115; CD115 antigen; CFMS; Colony stimulating factor 1 receptor; Colony stimulating factor I receptor; CSF 1 R; CSF 1R; CSF1 R; CSF1R; CSFR; FIM 2; FIM2; CSF1R_HUMAN
Description The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
Background of the target antigen This protein tyrosine kinase transmembrane receptor is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a member of the CSF1/PDGF receptor family of tyrosine protein kinases and contains 5 immunoglobulin like C2 type domains. CD115 is expressed by cells of the monocytic lineage and by progenitor cells. Mutations in this gene have been associated with a predisposition to myeloid malignancy.