Rabbit Anti-Human MCSF Receptor (pSer807 + pTyr809 ...

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Price

391 EUR

Catalog no.

SPC-954D-ALP

Size

100 µl

Net weight (g) 0.1
Total weight (kg) 1.4
Gene number 1436
Antibody's reactivity Human
Verified applications WB, AM
Raised in Rabbit
Country of production Canada
Protein number P07333
Storage recommendations -20°C
Antibody in cell Membrane
Stock availabilit In Stock
NCBI number NP_005202
Released date 29/Aug/2016
Tested reactivity To be tested
Tested applications To be tested
Warning information Non-hazardous
PubMed number Refer to PubMed
Bibliography Refer to PubMed
Shipping recommendations Blue Ice or 4°C
Representative figure link No Data Available
Antibody's specificity Detects 107.984 kDa.
Antibody's category Polyclonal Antibodies
Latin name Oryctolagus cuniculus
Antibody's purified from Peptide Affinity Purified
Group Polyclonals and antibodies
Antibody's target Human MCSF Receptor (pSer807 + pTyr809)
Recommended buffer for storage PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Antibody's concentration See included datasheet or contact our support service
Tissue specificity See included datasheet or contact our support service.
Antibody's full description Rabbit Anti-Human MCSF Receptor (pSer807 + pTyr809) Polyclonal
Antibody's recommended dilutions for use WB (1:250); optimal dilutions for assays should be determined by the user.
Test StressMark antibodies supplies antibodies that are for research of human proteins.
Antibody's datasheet Contact our support service to receive datasheet or other technical documentation.
Immunogen A phospho-specific peptide corresponding to residues surrounding Ser807 and Tyr809 of human CSF1R (AA804-813)
Certificate of analysis A 1:250 dilution of SPC-954 was sufficient for detection of MCSF Receptor (pSer807 + pTyr809) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Antibody's other name C FMS Antibody, CD 115 Antibody, CFMS Antibody, Colony stimulating factor 1 receptor Antibody, CSF 1R Antibody, CSF1R_HUMAN Antibody, FIM 2 Antibody, FMS Antibody, FMS proto oncogene Antibody, HDLS Antibody, Macrophage colony stimulating factor 1 receptor Antibody, MCSFR Antibody
Properties Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
About Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
Scientific context Receptor for colony stimulating factor-1 and links CSF 1 signals to Ras-ERK pathway. It is involved in hematopoesis and commits cells to differentiation. Most cancer mutations and chromosomal alterations appear to confer loss of function suggesting that absence of this gene causes hematopoeic malignancy via inability of cells to mature. Point mutations and partial deletions of CSF1R have been observed in acute myeloid leukemia and myelodysplastic syndrome respectively. A chromosomal translocation event leading to fusion of CSF1R to RBM6 has been observed in acute megakaryoblastic leukemia. In women, overexpression of CSF1R has been observed in breast and cervical cancers and is thought to play an autocrine role in stimulating cancer progression. Due to CSF1R role in cell proliferation its main role in cancer progression is likely oncogenic and maybe mediated through dysfunction of regulation of the receptor.