Anti-M-CSF Receptor(Tyr546), ALEXA Fluor 594

Subcellular locations N/A

Swiss Prot N/A

Gene ID 1436

Modification site Tyr546

Applications IF(IHC-P)

Concentration 1ug per 1ul

Excitation emission 590nm/617nm

Modification Phosphorylation

Conjugated Alexa conjugate 1

Conjugated with ALEXA FLUOR® 594

Applications with corresponding dilutions IF(IHC-P)(1:50-200)

Clonality Polyclonal Antibody

Target Protein/Peptide M-CSF Receptor Tyr546

Clone Polyclonal Antibodies

Purification method Purified by Protein A.

Type Conjugated Primary Antibody

Other name Anti-M-CSF Receptor(Tyr546)

Conjugation Alexa Fluor,ALEXA FLUOR® 594

Host organism Rabbit (Oryctolagus cuniculus)

Also known as M-CSF Receptor(Tyr546) Antibody

Properties For facs or microscopy Alexa 1 conjugate.

Specificity This antibody reacts specifically with M-CSF Receptor(Tyr546)

Cross reactive species Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)

Antigen Source KLH conjugated synthetic phosphopeptide derived from human CSF1R around the phosphorylation site of tyrosine 546

Storage Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.

Synonyms C FMS; CD 115; CD115; CD115 antigen; CFMS; Colony stimulating factor 1 receptor; Colony stimulating factor I receptor; CSF 1 R; CSF 1R; CSF1 R; CSF1R; CSFR; FIM 2; FIM2; CSF1R_HUMAN

Cross Reactive Species details No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.

Advisory Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.

Background information This protein tyrosine kinase transmembrane receptor is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a member of the CSF1/PDGF receptor family of tyrosine protein kinases and contains 5 immunoglobulin like C2 type domains. CD115 is expressed by cells of the monocytic lineage and by progenitor cells. Mutations in this gene have been associated with a predisposition to myeloid malignancy.

Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.